Modelling Biological clocks: a study of the Repressilator (Record no. 48825)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02043nam a2200217Ia 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160627s2008||||xx |||||||||||||| ||und|| |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Somdeb Ghosh |
| Relator term | author |
| 245 ## - TITLE STATEMENT | |
| Title | Modelling Biological clocks: a study of the Repressilator |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | xii; 62p. |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | 2008 |
| 502 ## - DISSERTATION NOTE | |
| Degree Type | M.Sc |
| 502 ## - DISSERTATION NOTE | |
| Name of granting institution | HBNI |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc | Biological clocks are found everywhere in the natural world. From circadian rhythms to pacemakers of the heart, biological clocks are an essential part of the smooth functioning of living organisms. They are composed of microscopic clocks which operate at the cellular level. The macroscopic clock functions by synchronisation of these smaller units through intercell coupling. These clocks keep time with amazing regularity even in the face of random external fluctuating effects or internal noise which are ubiquitous in the natural world. In order to attempt to understand the robustness of such clocks against stochastic effects, a model genetic circuit called the repressilator was constructed as a simple clock. The motivation is to find generic features which underlie the operation of complex biological clocks in a simple model. This thesis reviews the previous work done on single repressilators as well as on repressilators coupled by the quorum sensing mechanism. Numerical simulations are performed to study the properties of a mathematical model of the repressilator. A new mechanism is suggested by which repressilator circuits can be coupled. Numerical simulations of two repressilators coupled by this mechanism shows attractive phase synchronisation when their natural frequencies are identical. When the natural frequencies are distinct the results rule out entrainment and seem to indicate the absence phase-locking. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Biological Sciences |
| 653 10 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Biological Clocks |
| 720 1# - ADDED ENTRY--UNCONTROLLED NAME | |
| Thesis Advisor | Ronojoy Adhikari |
| Relator term | Thesis advisor [ths] |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://www.imsc.res.in/xmlui/handle/123456789/127 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | THESIS & DISSERTATION |
| Withdrawn status | Lost status | Damaged status | Not for loan | Current library | Uniform Resource Identifier | Koha item type |
|---|---|---|---|---|---|---|
| IMSc Library | http://www.imsc.res.in/xmlui/handle/123456789/127 | THESIS & DISSERTATION |